Health Benefits of Black Cumin Seed

Fig. 1. Health Benefits of Black Cumin Seed

Black Cumin (Nigella Sativa) Seed for Respiratory Health and Wellness

In a recent study, the immunomodulatory activity of Black Cumin Seed extracts (sample 1-4) were assessed by the release of mediators [Interleukin-2 (IL-2), Interleukin-6 (IL-6), Prostaglandin-E2 (PGE2)] in primary human T-lymphocytes, monocytes, and A549 human lung epithelial cells (Koshak et al., 2018). The details of the samples are given in Table 1.

Table 1. The Details of Samples Black Cumin Seed Extracts and Their Thymoquinone Concentration

Immunomodulatory activity of Black Cumin Seed Extracts

Fig. 2A.

Fig. 2B.

Fig. 2C.

Fig. 2. Effects of Black Cumin Seed Extracts on IL-2 (Fig. 2A), IL-6 (Fig. 2B) and PGE2 (Fig. 2C) production by SEB-induced T-lympocyte cells
(n=3), (*p<0.05, **p<0.01, ***p<0.001), (adapted from Koshak et al., 2018).

Fig. 3A.

Fig. 3B.

Fig. 3. Effects of Black Cumin Seed Extracts on IL-6 (Fig. 3A) and PGE2 (Fig. 3B) release by LPS-induced Monocyte
(n=3), (*p<0.05, **p<0.01, ***p<0.001), (adapted from Koshak et al., 2018).

Fig. 4. Effects of Black Cumin Seed Extracts on PGE2 production by A549 cell
(n=3), (*p<0.05, **p<0.01, ***p<0.001), (adapted from Koshak et al., 2018).

Nigellin^® AMBER and the cold pressed oil which are characterized by the highest level of Thymoquinone, showed the most remarkable effect on suppressing inflammatory mediators IL-2, IL-6, and PGE2 release from human T-lymphocytes (Fig. 2A, 2B and 2C). Also, these two extracts showed a marked suppression of IL-6 and PGE2 release in human monocytes (Fig. 3A and 3B). On the other hand, the extracts containing thymoquinone had a remarkable effect enhancing the release of PGE2 from A549 human lung epithelial cells (Fig. 4).